The Life Extension Blog: Red Clover Kills Prostate Cancer Cells

By Michael A. Smith, MD

More than 238,000 men will be diagnosed with prostate cancer in the United States, and nearly 30,000 will die from it.¹

In fact, about one in six men will be diagnosed with this condition during their lifetime.

And these epidemic statistics don?t even include the disabilities and deaths that occur in response to prostate cancer treatment.

So it?s always nice to see research results that point to a potential cancer killer like red clover. Let?s take a look at the study.

Red Clover?s Anti-Cancer Effects

Red clover contains a weak phytoestrogen called formononetin. Now before going any further, I know that some of you object to using a phytoestrogen for prostate cancer.

Please keep in mind that clinical studies have shown that some phytoestrogens have anti-cancer properties.^2,3 And the present study we?re talking about today supports the same conclusion.

In the study, researchers investigated the anti-cancer mechanisms involved in the effect of formononetin on prostate cancer cells. Their results suggest that higher concentrations of formononetin inhibited the proliferation of prostate cancer cells, by inactivating the enzymes responsible for cell growth, called signal-regulated kinase and mitogen-activated protein kinase.⁴

This inhibition of cell growth enzymes resulted in apoptosis (programed cell death) in prostate cancer cells. They concluded that red clover?s formononetin induces prostate cancer cell death ? at least in petri dishes.⁴

Considering that red clover plants were widely used clinically, the researchers also believed that their results provide a foundation for future development of different concentrations of red clover standardized to formononetin for treatment of prostate cancer.⁴

Other Phytoestrogens that Fight Against Prostate Cancer

Plant-derived compounds called isoflavones,which are abundant in soybeans, modulate estrogen signaling in the human body via interaction with estrogen receptors. Thus, these compounds are sometimes classified as ?phytoestrogens?.

Isoflavones have been investigated for their anti-cancer effects, but their ability to affect hormone-responsive tissues appears to influence the prostate. Evidence suggests that isoflavones decrease free serum testosterone levels and may inhibit testosterone-mediated prostate cell growth.⁵

These compounds were also shown to block the activity of 5?-reductase, the enzyme that converts testosterone to dihydrotestosterone (DHT), which promotes prostate growth.⁶

Supplementation with soy isoflavones has been found to reduce PSA levels in men with prostate cancer⁷, and a soy-based dietary supplement containing isoflavones, lycopene, silymarin, and antioxidants was shown to significantly delay PSA progression in patients who underwent curative treatment for prostate cancer⁸.

In addition to preventing prostate cell proliferation, isoflavones may increase programmed cell death (i.e., apoptosis) in low-to-moderate grade tumors from prostate cancer patients.

Of Course, Prevention is Always Better

No single cause of prostate cancer has ever been determined, but the single biggest risk factor for prostate cancer is eating products that contain animal fat. In an old well-designed study involving over 6,000 men, those who routinely ate milk, cheese, eggs and meat had a 3.6 times greater risk of fatal prostate cancer than those who did not.⁹

A more recent case-control study published on the National Cancer Institute?s website shows a higher risk of prostate cancer with increased intake of total calories, red meat, and animal fat and protein. Yet a higher consumption of allium vegetables, peppers, and mushrooms are associated with reduced risk.¹⁰

And lastly, a study designed to examine fat intake in relation to lethal prostate cancer and all-cause mortality was published this month in the Journal of the American Medical Association.

The results showed that among men with non-metastatic prostate cancer (cancer that is contained within the prostate gland), replacing carbohydrates and animal fat with vegetable fat reduces the risk of all-cause mortality.

The authors concluded that the potential benefit of vegetable fat for prostate cancer-specific outcomes merits further research.¹¹

So what does this mean? Pretty simple. Eat less animal fat and more vegetables! Something all of us inherently know we should be doing.

References:

1. Available at: http://www.cancer.org/cancer/prostatecancer/detailedguide/prostate-cancer-key-statistics.
2. Anticancer Res. 2013 Jan;33(1):39-44.
3. Maturitas. 2013 Jun;75(2):125-30. doi: 10.1016/j.maturitas.2013.03.006. Epub 2013 Apr 6.
4. Horm Metab Res. 2012 Apr;44(4):263-7.
5. Prostate. 2004 May 1;59(2):141-7.
6. J Endocrinol. 1995 Nov;147(2):295-302.
7. J AOAC Int. 2006 Jul-Aug;89(4):1121-34.
8. Eur Urol. 2005 Dec;48(6):922-30.
9. Am J Epidemiol. 1984 Aug;120(2):244-50.
10. National Cancer Institute. http://dceg.cancer.gov/research/cancer-types/prostate/shanghai-case-control-study-prostate-cancer. Accessed 6/28/2013.
11. JAMA Intern Med. 2013 Jun;10:1-8.

Source: http://blog.lef.org/2013/07/red-clover-kills-prostate-cancer-cells.html

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Together with George Mason University, tomorrow the Bipartisan Policy Center wil...

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Source: http://www.facebook.com/BipartisanPolicyCenter/posts/10151806615785086

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First First-to-File Patent - Patent Law Blog (Patently-O)

[unable to retrieve full-text content]By Dennis Crouch The first post-AIA patent issued recently ? Design Patent No. D685,381 directed to a foldable laptop stand and owned by the UK company Bluelounge. The application sailed-through as part of the design ...

Source: http://www.patentlyo.com/patent/2013/07/the-first-post-aia-patent-issued-recently-design-patent-no-d685381-directed-to-a-foldable-laptop-stand-and-owned-by-the.html

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Dr. Pecco is a mentally unstable dentist from Rome who gained...

Dr. Pecco is a mentally unstable dentist from Rome who gained notoriety when some of his patients went missing. He was investigated but never charged. In his spare time he hunts great white sharks in the Mediterranean Sea, drives his Countach really fast, and makes awesome synth music.

Source: http://2087.tumblr.com/post/56668577496

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Energy Watchdog 'Failing Consumers', Say MPs

By Tadhg Enright, Business Reporter

The energy watchdog, Ofgem, is failing consumers and undermining trust in the market, a group of MPs have said - urging it to "use its teeth a bit more".

A report by the Energy and Climate Change Select Committee has said there is a "lack of transparency" about profits made by the Big Six energy providers.

Committee member and Lib Dem MP Sir Robert Smith said: "At a time when many people are struggling with the rising costs of energy, consumers need reassurance that the profits being made by the Big Six are not excessive.

"Unfortunately, the complex vertically integrated structure of these companies means that working out exactly how their profits are made requires forensic accountants."

Labour MP John Robertson added: "Ofgem needs to use its teeth a bit more and force the energy companies to do everything they can to prove that they are squeaky clean when it comes to making and reporting their profits."

There has been long standing criticism of the UK energy market in which six major competitors show little evidence of competing with each other on price.

Rising prices for consumers in recent years has been blamed on higher wholesale prices for energy providers however the Committee notes in its report that many of Britain's major providers are generators of energy and therefore profit from higher wholesale prices too.

The Big Six have also been criticised for offering a confusing range of tariffs which give the impression of greater consumer choice but offer little in the way of discounts.

British Gas and EDF customer Mary Phillips told Sky News that in the winter she frequently has to choose between spending on food or fuel, and that competition in the energy market has done nothing to help.

She said: "I keep getting notes from all these different energy companies saying that they're making their bills much easier to understand. You're joking!

"Every single different supplier says that they're going to give me a much better deal than all the other suppliers. I don't believe it really. I think they might do it for about three months and then it will all go up suddenly."

As the industry's watchdog, Ofgem has the power to order an inquiry into competition in the energy market but has chosen not to do so.? Instead it hopes that the threat of such a forensic analysis of the Big Six's energy practices will encourage them to clean up their acts.

Ofgem's Rachel Fletcher said: "We share the committee's goal of restoring consumers' trust.

"We agree with the committee that suppliers have been poor at communicating with their customers.

"Ofgem has made energy companies produce yearly financial statements, which have been reviewed twice by independent accountants and found to be fit for purpose."

The report also criticises the Government for not doing enough to help millions of low-income families living in poorly insulated homes and who struggle with fuel poverty.

The MPs argue that programmes to help protect the most vulnerable should be funded through direct taxation rather than levies on the bills of those who can afford it.

Sir Robert said: "Fuel poverty is getting worse as energy prices rise making it all the more critical that the Government must respond to the Hills Review as a matter of urgency.

"Tax-funded public spending is a less regressive mechanism than levies on energy bills, which can hit some of the poorest hardest. Shifting the emphasis from levies to taxation would help protect vulnerable households."

Source: http://news.sky.com/story/1121455

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Evomail for iPhone and iPad review: Full email folder support for the organizationally obsessed!

Evomail is an email app for iPhone and iPad that takes a lot of the same features we love from Mailbox, Dispatch, and more but adds certain highly wanted features that a lot of others unfortunately lack, such as folder support. Evomail currently supports Gmail, iCloud, and Yahoo! accounts which makes it a pretty relevant option for almost everyone.

To start using Evomail, you just need to configure your mail accounts. While Gmail, iCloud, and Yahoo! are already supported, the developer has said that more mail account types will be coming in the future as well. Once you're signed in you're ready to start swiping your way to an empty inbox.

Much like other popular mail apps, Evomail uses swipe gestures to let you filter your way through emails faster. Swipe to the right to mark a message as complete and swipe to the left to delete it. Tapping on a message will open it. You can star it or share it along the top or return to your inbox.

Along the bottom of the message view you can interact with messages in more advanced ways. From here you can put a message inside a folder that you've created, mark it for later, mark it as done, or delete it. If you choose to mark it for later you can choose from three quick options; later today, tomorrow, or next week. If you want a more detailed way to mark for later, you can do so by tapping on the carat below the quick settings. From here you can choose a specific date and time for the message to re-appear in your inbox.

From the main menu of Evomail you can dig deeper into individual account settings and change things such as signatures on a per-account basis. There aren't a ton of options but it gets the job done. I'd really like to see some options to set notifications on a per account basis such as disabling push for accounts I don't really need it for.

The good

• Folder support! If you miss being able to file things away in apps like Mailbox, Evomail gives you your organization power back
• Great interface with menus that not only make sense, but are placed logically
• Advanced snooze options for custom dates and times
• Push notifications
• Signatures on a per account basis

The bad

• Push notifications can be off or on, not on a per account basis, definitely not a deal breaker but it would be a nice addition in a future update
• No Exchange support

The bottom line

Evomail for iPhone and iPad is not only beautifully designed but provides a happy medium between productivity powerhouse and full on mail suite. With swipe gestures for marking messages quickly, you'll be able to empty your inbox in no time. Features like folder support also gives you the ability to organize when you'd like and when you have time without relying on a secondary option such as the native Mail app.

Source: http://www.imore.com/evomail-iphone-and-ipad-review-swipe-your-way-empty-inbox

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Cuban baseball player Misael Siverio defects to United States

After only being in the United States for a few hours, Cuban baseball player Misael Siverio, 24, did not waste any time leaving the National Team, deciding to defect.

The Cuban team is in Iowa playing some exhibition games against U.S. colleges starting Thursday. The lefty with the help of some friends left the hotel where the team

was staying Tuesday around 10 p.m.

"It is not easy leaving behind what is yours, but after a giving it a lot of thought I made this decision for my future and for my family," Silverio said. "My dream, of course, is to make the Major Leagues, and starting today I will start doing what I need to do to accomplish that."

This season, in the Cuban league, the lefty had a 1.90 ERA and batters were hitting .245 off of him.

Source: http://www.miamiherald.com/2013/07/17/3505511/cuban-baseball-player-misael-siverio.html

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Kim Kardashian writes she's taking time to 'fully embrace motherhood'

Kim Kardashian took the time to thank her fans and briefly talked about motherhood in a blog post on her official website on Wednesday, July 17.

In the post, which is simply titled "Thank You," Kardashian said she has been reading fan messages and taking time to "fully embrace motherhood."

"These past couple of weeks have been filled with the most exciting experiences of my life. I'm enjoying this time to fully embrace motherhood and spend time at home with my family," Kardashian wrote. "I've been reading all of your messages and want to thank you all for your sweet thoughts and best wishes."

"It truly means everything to me," she added. "I am so blessed to have the support of my family and fans in this beautiful moment. Xo."

Kardashian and her boyfriend, rapper Kanye West, welcomed their daughter North West on June 15. Kardashian gave birth five weeks early. Her sister Khloe Kardashian-Odom called the new addition to the family a "miracle" in a Tweet on June 16.

The "Keeping Up with the Kardashians" star stayed relatively quiet on several social media platforms for a few weeks after giving birth to her daughter. She has now started regularly Tweeting and posting on Instagram.

(Copyright ?2013 OnTheRedCarpet.com. All Rights Reserved.)

Source: http://www.ontheredcarpet.com/Kim-Kardashian-writes-shes-taking-time-to-fully-embrace-motherhood/9176606

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Ride The MAX is coming to Downtown Arlington Texas and #UTArlington! The bus ser...

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Sales tax increases in every Coast city this year | Business | The Sun ...

South Mississippi has 2 million reasons to be encouraged by the Coast economy after Monday's report that all 12 cities collected more sales tax in the state fiscal year that ended June 30.

Sales tax diversions for fiscal year 2013 were $2.1 million ahead of 2012, led by Biloxi's increase of $491,000. Gulfport also had a strong year, taking in $342,000 more than the previous year and D'Iberville was up by $241,000.

Monday's numbers from the Mississippi Department of Revenue follows last week's encouraging Business Owners Confidence Report from the Gulf Coast Business Council. For the second quarter of 2013, the confidence index of local business leaders reached its highest level in two years.

"When asked about the current economy (as compared to six months prior) the index reached its highest level in the six years which the survey has been administered," the report said.

The survey found that as the sales tax base in South Mississippi continues to grow, it reinforces business leaders' opinions that the Coast economy is improving.

Those who responded to the survey were more confident about the overall economy than they were about their own industry. While 28 percent said they plan to hire additional staff in the next six months, 20 percent said they are considering cutting staff.

The still cautious recovery of the economy also showed up in the report of June sales tax diversions for May sales.

Gulfport saw its best May sales tax revenue since 2009 while four other cities in South Mississippi had lower sales in May than a year ago.

Collectively, the 12 cities had $81,000 higher tax collections than in May 2012, although Bay St. Louis, Biloxi, Diamondhead and Ocean Springs saw decreases from a year ago.

Gulfport had the biggest gains -- up $68,000 from a year ago.

Source: http://www.sunherald.com/2013/07/15/4797565/sales-tax-revenue-continues-its.html

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EU to Probe Germany's Decade-Old Renewable Energy Law

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Source: www.ibtimes.com --- Monday, July 15, 2013
Law may breach regional European Commission competition rules says Der Spiegel report ...

Source: http://www.ibtimes.comhttp:0//www.ibtimes.co.in/articles/490316/20130715/renewable-energy-law-eu-angela-merkel-joaquin.htm

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Dutch football fans recall 'Fails of the Season' (Video)

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Japan PM to protect farmers in trade deal

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Source: www.ft.com --- Saturday, July 13, 2013
Abe promises not to sacrifice farmers in the Trans-Pacific Partnership, as third round of talks towards creating a free trade bloc starts on Monday ...

Source: http://www.ft.com/cms/s/0/d9efc06c-ec4c-11e2-a0a4-00144feabdc0.html?ftcamp=published_links/rss/home_asia/feed//product

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