Sunday, December 4, 2011

Color for Facebook iPhone app hands-on

Color failed to live up to the massive level of hype that surrounded its launch, as CEO and Lala-cofounder Bill Nguyen will be the first to tell you. So, naturally, the company went into hiding, only to relaunch as something different entirely. The fruits of that hibernation are finally starting to surface, in the form of Color for Facebook, which is now in closed beta. As its title suggests, the app is heavily reliant on Zuckerberg's social network, playing on the site's "like" feature with a gesture of its own: the "visit." As the company puts it, "the status update needs an update."

The visit is a short video clip. You broadcast a 30-second, soundless live stream from your phone that your Facebook friends watch, like and comment on. This isn't UStream here, of course: it's just a way of sharing a small slice of your daily life -- something interesting or even mundane, a way to connect with friends when a pithy status update or blurrycam still won't cut it. At least, that's Color's elevator pitch this go' round. We managed to get a sneak peek at the app, and while we're still playing with it, we do have some early impressions. So is the second time the charm for Color? Meet us past the break to find out.

Continue reading Color for Facebook iPhone app hands-on

Color for Facebook iPhone app hands-on originally appeared on Engadget on Thu, 01 Dec 2011 15:55:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2011/12/01/color-for-facebook-iphone-app-hands-on/

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Saturday, December 3, 2011

Engadget Podcast 266 - 12.02.2011

Listener, it's been a weird week. Big Brother's inside your phone, a tasty new OS is inside your phone, and now it's even easier to livestream your life from your phone. How do all these revelations change the way you'll go about your gadgety business? There's only one way to find out: listen, listener, to the Engadget Podcast.

Host: Tim Stevens, Brian Heater
Guest: Terrence O'Brien
Producer: Trent Wolbe
Music: All The Small Things

01:20 - Carrier IQ: What it is, what it isn't, and what you need to know
09:38 - ASUS Eee Pad Transformer Prime review
17:20 - Android 4.0 Ice Cream Sandwich review
26:40 - FCC finds AT&T merger not in public interest, Genachowski issues order to hold trial
30:00 - AT&T, Deutsche Telekom withdraw FCC application for T-Mobile merger, look toward DoJ
32:10 - AT&T blows a gasket, calls FCC report 'an advocacy piece, not analysis'
36:25 - Spotify gets app-happy with new platform (video)
40:00 - Spotify apps hands-on
45:50 - Color for Facebook iPhone app hands-on
52:44 - Listener questions







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Engadget Podcast 266 - 12.02.2011 originally appeared on Engadget on Fri, 02 Dec 2011 11:40:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2011/12/02/engadget-podcast-266-12-02-2011/

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Big East will seek dismissal of WVU lawsuit Dec. 5

(AP) ? The Big East will seek dismissal of a West Virginia University lawsuit aimed at invalidating conference bylaws and speeding up the Mountaineers' departure for the Big 12.

At a scheduling conference in Morgantown, Big East attorneys said they plan to file a motion Monday in Monongalia County Circuit Court, asking Circuit Judge Russell Clawges to either dismiss the case or put it on hold while a parallel lawsuit plays out in Rhode Island. That's where the Big East is based.

Attorney Benjamin Block said the Big East believes WVU has failed to lay a foundation for its claim that the bylaws are invalid. But if the judge believes there are grounds to move forward, he said, the case should be heard in Rhode Island.

WVU is trying to have the Big East's breach-of-contract lawsuit tossed from the Rhode Island court, arguing it has sovereign immunity as an agency of the state of West Virginia. A hearing on that motion to dismiss is set for Dec. 16, the lawyers said Thursday. In it, WVU also notes that it filed the lawsuit in Morgantown four days before the conference countersued.

The Mountaineers are making plans to join the Big 12 in 2012. WVU argues it should be allowed to leave now because the Big East breached its fiduciary duty by failing to maintain a balance between football-playing and non-football members.

But the Big East is seeking unspecified damages and an order that West Virginia stay in the conference for 27 months. Commissioner John Marinatto says West Virginia helped construct the bylaws and agreed to abide by them.

WVU has already sent half of the required $5 million exit fee to the Big East. The university contends that by accepting the down payment, the Big East agreed to the immediate withdrawal.

WVU attorneys pressed Clawges to fast-track the West Virginia lawsuit, saying the university needs a resolution by June 30.

"We need to know whether we're going to stay or go," said WVU lawyer Stephen LaCagnin.

However, Clawges was doubtful such a timeline can be met.

"My immediate reaction is ... it ain't gonna happen," the judge said.

Clawges agreed to an aggressive schedule for the West Virginia case but told the attorneys it will be up to them to make it happen. He also noted it could end with a settlement before ever getting to a jury.

"This is probably going to be worked out ? as opposed to a jury room ? in a conference room," he said.

WVU said it will reply to the Big East's motion to dismiss by Dec. 9, and Clawges has scheduled a hearing on the motions for 1 p.m. Dec. 19 in Morgantown. He may rule from the bench that day.

The trial is tentatively set for June 25, 2012.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2011-12-01-West%20Virginia-Big%20East/id-287c41930d894c33a0e0fbf7a9ce6c45

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Friday, December 2, 2011

'Super 8' And More: 10 Best Film Scores Of 2011

'Hugo' and 'War Horse' also make the list of film music that moved us this year.
By Kara Warner


Joel Courtney, Ryan Lee and Riley Griffiths in "Super 8"
Photo: Paramount

Continuing with our comprehensive collection of best-of 2011 movie stories, in which we count down our favorite elements of our obsessive movie love (including the top 20 movie trailers and the ), this compilation is focused on yet another crucial element involved in a film's success: the music. A good film score can make or break a scene, move you to or prevent you from shedding tears, make you smile. A great one can do all of the above. Here's a look at our favorite musical masterworks this year.

10. "Rango"
This south-of-the-border-inspired score was a clever and creative companion to Gore Verbinski and Johnny Depp's quirky animated western about a domesticated chameleon who dreams of becoming an actor and leading a more adventurous life. Hans Zimmer's spin on spaghetti-western sound with an authentic kick of Mexican folk from Los Lobos made for a perfect musical marriage.

9. "The Muppets"
If there's anything better than seeing the Muppets back on the big screen, it's the concerted effort put into the film's multiple musical layers. ‪For example, you can't talk about composer Christophe Beck's excellent original instrumentals without mentioning "Flight of the Conchords" star-turned-music-supervisor Bret McKenzie's catchy tunes "Life's a Happy Song" or "Man or Muppet." Not to mention the star-studded Green Album that features favorite artists including Weezer, OK Go, the Fray, My Morning Jacket, Amy Lee, Feist, Hayley Williams and Rachael Yamagata belting out updated versions of classic Muppet tunes.

8. "War Horse" and "The Adventures of Tintin"
‪Any year in which John Williams composes a film score is a year in which you'll likely find his work named to the tops of all the best-of lists. And this year Williams is serving up the one-two punch of "War Horse" and "Tintin," both of which feature the Oscar winner's sweeping, stand-out, magical touch. They are paired together on this list because they're both uniquely terrific but it's too hard to rank one above the other.

7. "The Artist"
‪ One of the year's most buzzworthy films, "The Artist" features an appropriately memorable score. Composed by Ludovic Bource, this score is light and happy with a delicate and glamorous finish reminiscent of the film's 1920s setting.

6. "Hugo"
‪It makes perfect sense that Oscar-winning director Martin Scorsese would pair up with Oscar-winning composer Howard Shore to score a family-friendly crowd-pleaser. There's a sense of wonder, magic and magnitude in Shore's music that fits perfectly with the film's underlying theme.

5. "Midnight in Paris"
‪Similar to the variety of music featured in "The Muppets," Woody Allen chose to incorporate old-school classics by Cole Porter, Benny Goodman and Duke Ellington, along with original instrumental music composed by Stephane Wrembel that further enhanced the film's love letter to nostalgia and self-reflection.

4. "Drive"
‪As much talk as there has been surrounding the story and performances in Nicolas Refn's violent thriller "Drive," the film's score, composed by Cliff Martinez, has been getting just as much attention for its unique and classically cool '80s retro synthesizer sound. Much like how Trent Reznor and Atticus Ross' different and daring score for "The Social Network" took the critics by storm, Martinez's work on "Drive" is poised to do the same.

3. "The Girl With the Dragon Tattoo"
‪Speaking of Trent Reznor and Atticus Ross, fans can't wait to hear and see what last year's Oscar winners have done with the music for David Fincher's adaptation of "The Girl With the Dragon Tattoo." Although the film doesn't open for a few more weeks, a special sneak peek of the score has appeared online via the company producing it. Unsurprisingly, the music is as chilling, complex and captivating as the film's poster and trailer.

2. "Harry Potter and the Deathly Hallows, Part 2"
‪In looking at prolific composer Alexandre Desplat's résumé, it's a wonder the man has any time to sleep with the number of film scores he churns out annually. Not that we'll ever complain, however, because the fruits of his 2011 labor include "The Tree of Life," "Carnage," "Extremely Loud and Incredibly Close" and our #2 favorite score of the year: "Harry Potter and the Deathly Hallows, Part 2." Desplat's work had our emotions perfectly in tune with what played out on screen: on the edge of our seats, prepped for battle, celebratory and sniffling.

1. "Super 8"
There are several wonderfully epic scores on this list, but the biggest, baddest, bell-iest was Michael Giacchino's brilliant music for "Super 8." It is so many things: sweet, sentimental, wondrous, fascinating ... Plus, in trying to pinpoint that very specific tintinnabular sound that plays throughout the film, we learned about a new instrument: a celesta, which Giacchino told us is kind of a "bell piano."

For breaking news, celebrity columns, humor and more — updated around the clock — visit MTVMoviesBlog.com.

Source: http://www.mtv.com/news/articles/1675269/super-8-best-film-scores.jhtml

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NBC The Office, Whitney & Prime Suspect Preview Videos

Happy Thursday my friends! It may be December but that doesn?t mean you are stuck with reruns. You can see what I am talking about in the below preview videos of The Office, Whitney and Prime Suspect, sweet! NBC has a killer line-up tonight, which includes all new episodes of Whitney, Prime Suspect and The Office. Three of my favorite shows I must say. On The Office guest star Maura Tierney rolls into town as Robert California?s wife. As you can imagine things get interesting when Robert a.k.a. James Spader, realizes that there is not a spot for his wife in The Office. Next up we have the show Whitney which I am so loving. This week the one and only Chelsea Handler guest stars as Whitney?s psychiatrist. Oh yes our girl has a sleeping problem and is looking for Handler to fix it. This is going to be a must see episode for sure. Last but by no means least, there is Prime Suspect. I swear this show gets better and better each week. Tonight fans will see Jay Mohr and Laura Innes as guest stars, love both of them but what case are they involved in? You can [...]

Source: http://feedproxy.google.com/~r/RightCelebrity/~3/r7x-_8itfGw/

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Thursday, December 1, 2011

PROMISES, PROMISES: Records shielded by candidates (AP)

WASHINGTON ? In the final weeks of Mitt Romney's term as Massachusetts governor, a small team of aides combed through statehouse filing cabinets. They filled more than 630 cartons with papers destined for the state archives as the primary documentary legacy of his administration. One floor, though, was almost completely off limits to them: Romney's inner sanctum, his third-floor office.

The former legislative affairs director who headed the archiving effort, John O'Keefe, recalls that his team was given a stack of Romney's public schedules over four years and a limited variety of other documents from the governor's executive office, but not much else. "We were told we were not in charge of archiving the third floor," he says.

The mystery deepened recently when the chief legal counsel for Romney's Democratic successor, Gov. Deval Patrick, said that just before Patrick took office, material on a state government web server that housed Romney's emails was erased. Top Romney aides also bought and removed their state-issued computer hard drives, and remaining leased computers were replaced. Romney said he followed the law in authorizing the purge, and his campaign aides said their actions were based on a 1997 Massachusetts court ruling that all governors' records are private.

Romney's selective policy toward public access and preservation of his executive records raises stark questions about how transparent his administration would be if he were to become president.

He's not alone. Other leading candidates for the presidency ? incumbent Barack Obama and Texas Gov. Rick Perry ? have touted their commitment to transparency, but their administrations also have been selective at times in the records they disclose. They have limited, stalled or denied access when it suited their purposes.

"What I wish Americans could expect is a politician who talked a good game and walked a good game, too," said Ken Bunting, executive director of the nonpartisan National Freedom of Information Coalition. "The reality is everybody gives lip service to transparency and accountability."

Romney's submission of paper documents to the Massachusetts archives was made "in the interest of transparency and to help provide a record of his time in office," said Eric Fehrnstrom, a senior campaign adviser. But the holdings in the archives are far from comprehensive. An Associated Press reporter sent from Washington earlier this fall spent a week examining the Romney archives, but did not find paper copies of any emails to or from Romney or any internal calendars or in-house memos ? all commonly used by governors. There are no state archives records accounting for what happened to those materials.

The growing use by government agencies and political campaigns of new channels of electronic communication, including text messages, online videos and social media services, has opened new dimensions in the availability of public records. But presidential candidates haven't been especially transparent.

"There's the potential for a lot more raw information than in the past as emails and other electronic communications replace phone and face-to-face conversations," said Peter Scheer, executive director of the First Amendment Coalition, a nonprofit public interest group. "The problem is we're seeing officials and governments moving more and more to shield those materials from public access."

Only about one-quarter of the 630 cartons of Romney paper records are available for inspection at the Massachusetts archives. State legal officials have yet to say whether the 1997 court ruling allows access to the other material. Even if they do, Assistant State Archivist Michael Comeau said, staff shortages and time-consuming redaction checks could extend delays close to the 2012 election. More than 75 cartons examined by the AP revealed staff and legislative documents but no internal materials written to or from Romney himself ? except for ceremonial bill-signing and official letters.

As governor, Romney's careful line on providing records was based on the 1997 court ruling that "the governor is not explicitly included" among other state officials and agencies covered by the state's Public Records Law, which generally requires agencies to submit to records requests. Other governors since 1997 have interpreted the ruling similarly.

The AP submitted detailed questions to Romney about how his administration handled public records when he was governor, but the campaign responded with only a brief statement: "The governor's office in Massachusetts is not subject to the state's public records law. As a legal matter, it is not required to disclose any documents."

Fehrnstrom, who was Romney's chief spokesman during that era, said the Romney campaign does not possess any remaining gubernatorial records outside of the Massachusetts archives.

After The Boston Globe first reported that his aides had purged electronic files, Romney said the deleted materials might have contained confidential records. Still, when Romney's archive team found confidential files at the end of his administration, they separated those materials from thousands of other documents that were turned over to the archives. O'Keefe, now city manager in Manchester, Vt., recalled that anything that appeared "confidential in nature" was turned over to a private vendor for shredding.

Suggesting that Romney's Massachusetts administration "deliberately sought to delete public records" in advance of his 2007 presidential run, the Democratic National Committee has pressed three separate Massachusetts public records requests for more background on the purge. Romney's campaign has responded with its own request to Patrick's office asking for any evidence of collaboration between his staff and Obama re-election officials.

Gavi Wolfe, a legal counsel for the Boston office of the American Civil Liberties Union, said Romney's authorization of the purging of third-floor electronic files set an "alarming" precedent: "I would be concerned about the chief executive wanting to shield the actions of his administration from public scrutiny." Romney has waved off those concerns, saying that if elected, his presidential administration "would do what's required by the law and then some."

In three years in the White House, Obama set an even more ambitious standard. Obama signed an executive order on his first day in office, committing publicly to improving transparency and setting clear goals for federal agencies to respond quickly and expansively to records requests. His directive led to the opening of White House visitor logs and plans to improve response times and declassify outdated secret documents.

But many of Obama's broad commitments have not been met. In the face of criticism, the Justice Department abandoned a proposal that would have allowed officials to pretend that some government files didn't exist when people asked to see them. And the government completely turned down records in one-third of all requests in 2010 ? even censoring 194 pages of internal emails about Obama's Open Government directive.

The White House and Energy Department have been hesitant and selective turning over records related to the GOP-led congressional investigation of Solyndra, the failed California solar panel company. The AP pressed three separate appeals for records in September, but Energy Department officials said they would take months because of the number of documents and requests to read them. In early October, as Congress threatened to issue subpoenas, administration officials quickly released thousands of pages and DVDs filled with emails.

White House officials would not comment on the sudden shift. Campaign spokesman Ben LaBolt said, "The president and this administration are changing the ways Washington works in terms of transparency."

In Texas, Perry has made similar claims, pointing to broad swaths of electronic data that his administration has made available online ? from state agency expenditures to death certificates. But Perry's administration has also blocked viewing of expenditures for his security guards when he travels. He also barred access to his reviews of death penalty cases and to his private calendars, even though his predecessor, former President George W. Bush, had made both available when he was governor.

"The people of America aren't seeing the real Rick Perry," said Keith Elkins, executive director of the Freedom of Information Foundation of Texas. "They may get a glimpse of him on the campaign trail, but the real record has been hidden and carefully parceled out."

___

Associated Press writers Brett J. Blackledge, Matthew Daly and Jack Gillum contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/gop/*http%3A//news.yahoo.com/s/ap/20111130/ap_on_el_pr/us_campaigns_transparency

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When inflexibility is counterproductive: Mechanism of UV-induced DNA Dewar lesion revealed

When inflexibility is counterproductive: Mechanism of UV-induced DNA Dewar lesion revealed

Monday, November 28, 2011

Excessive exposure to ultraviolet (UV) radiation of sunlight can result in skin damage and may even induce skin cancers. Irradiation with UV light causes mutations in the DNA, which can interfere with or even inhibit the read-out of genetic information and hence affect the cell function. The Dewar lesion is one of the major UV-induced reaction products, which can itself generate mutations. Understanding the mechanism that leads to the formation of the Dewar lesion is therefore of great interest.Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich have now shown that the DNA backbone (the double-stranded scaffold which bears the subunits that encode the genetic information) plays a decisive role in the process. The Dewar lesion can be generated only if the backbone of the DNA is intact. If the DNA strand itself is broken, and therefore more flexible, the Dewar reaction will not take place. The process reveals a surprisingly paradoxical facet of the DNA structure. On the one hand, an unbroken backbone is a prerequisite for DNA function and for cell survival; on the other, the intact backbone favors the formation of Dewar lesions upon exposure to UV, and so facilitates UV-induced mutagenesis. (Angewandte Chemie, 23 November 2011)

UV radiation induces molecular changes in DNA structure, which can lead to genetic mutations and finally to cell death. Energetic UV light primarily produces two types of photochemical damage in the subunits of the DNA - cyclobutane pyrimidine dimers (CPDs) and (6-4) photoproducts. Both types of lesion are due to cross-linking of adjacent pyrimidine bases on the same DNA strand. Continued exposure to UV light transforms the (6-4) photoproduct into a Dewar lesion by inducing further structural changes. Dewar lesions are stable end-products of continuous exposure to sunlight. Moreover, they are highly mutagenic, i.e. they can themselves induce a range of further mutations. "While the chemical changes that give rise to CPDs and (6-4) photoproducts are already well understood, this is not true for the Dewar lesion," says LMU chemist Professor Thomas Carell, who is also a member of the Center for Integrated Protein Science Munich (CiPSM), one of the Clusters of Excellence at LMU.

In a joint project within the SFB749 initiative Carells group together with research teams led by LMU physicist Professor Wolfgang Zinth (CiPSM) and Regina de Vivie-Riedle of the Department of Chemistry, could show that the backbone of the DNA plays a crucial role in the formation of the Dewar lesion. The backbone consists of repeating units made up of sugars and phosphates, which link the succession of bases that represent the protein-coding information in the DNA. "To our surprise, we found that the Dewar lesion can be generated only if the backbone in the affected region is intact," Carell explains. "If the continuity of the backbone is interrupted, or if the cross-linked base-pairs alone are exposed to sunlight, the Dewar structure fails to form." Thus, an interdisciplinary cooperation, which included chemists, physicists and theorists has, for the first time, been able to dissect the photochemical formation of the Dewar lesion at the atomic level. "Our results also show that the process is remarkably effective; indeed, this is one of the most efficient light-induced reactions known to occur within the DNA," says physicist Wolfgang Zinth.

Theoretical considerations yielded further insights into the details of the Dewar isomerization. "To follow the photochemical reaction dynamics on a high level of theory we came up with a hybrid method that separates the molecular system into subsystems treated on different quantum mechanical levels. This hierarchic strategy allows us to evaluate the dynamics of the complete system," says de Vivie-Riedle. Based on these calculations, the researchers were able precisely to define the role of the DNA backbone in the formation of the Dewar lesion. Cleavage of the backbone makes the molecule more flexible. Under these conditions, the (6-4) lesion will be protected and the system returns via a photophysical pathway back to its initial state. In contrast, an intact backbone keeps the molecule rigid, and strains the pyrimidine ring structure. The result is that only those atoms that must rearrange to form the Dewar isomer remain mobile, which favors the reaction that leads to the stable Dewar lesion.

###

Ludwig-Maximilians-Universit?t M?nchen: http://www.uni-muenchen.de

Thanks to Ludwig-Maximilians-Universit?t M?nchen for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/115498/When_inflexibility_is_counterproductive__Mechanism_of_UV_induced_DNA_Dewar_lesion_revealed

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